Selvaraj Stephen

Department of Microbiology, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth (Deemed-to-be-University), Pondicherry, India

Publications

  • Original Article   
    Validation of a New Scrub typhus Rapid Kit-Standard Q Tsutsugamushi IgM/IgG
    Author(s): Selvaraj Stephen*, Jothimani Pradeep, Shanmuga Priya T and Kengamuthu Sarangapani

    A new rapid kit manufactured in India, Standard Q Tsutsugamushi IgM/IgG (SD Biosensor) for Scrub typhus diagnosis targeting both IgM and IgG antibodies to Orientia tsutsugamushi, is validated for its performance. The result obtained is compared keeping ST IgM and ST IgG ELISA (Scrub Typhus Detect IgM/IgG ELISA System, InBios International, California, USA) as reference standard. Percentage sensitivity, specificity, positive predictive value and negative predictive values for SD Biosensor IgM were 97.52, 96.90, 96.72 and 97.66 respectively, with a kappa value of 0.944, which is considered as ‘very good’. However with reference IgG antibody detection, the percentage sensitivity, specificity, positive predictive value and negative predictive value were 49.15, 98.48, 47.20 and 68.42 respectively with a kappa value of 0.489, which is considered as ‘moderate’. In acu.. Read More»

    Abstract PDF