A Review on Genes Involved in Alzheimer?s Disease | 93447

Journal of Research in Medical and Dental Science
eISSN No. 2347-2367 pISSN No. 2347-2545

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A Review on Genes Involved in Alzheimer?s Disease

Author(s): Avneet Kaur*, Chinky Sharma, Durgesh Wadhwa, Deepika Arora, Ajay Bilandi


It has been very well known that the protein’s 3- Dimensional structure plays major role in maintaining biological functions. Their primary sequence codes for the relevant information required for their folding into 3-D structure either with the assistance or without the assistance of chaperones. In this case, the protein does not acquire its destined con?uraton? it may lead to several diseases and one of them is Alzheimer’s disease (AD). AD is amongst one of most abundant neurological disorder which has global impact. In this the proteins and the genes involved in AD has been reviewed. It has been suggested by the scientists that the alterations in the β-sheet like motifs of proteins lead to the AD. Although change in β-sheet like motifs are common to protein misfolding, but misfolding from the α-helix to β-sheet is the property of amyloid deposits. Therefore, abnormalities in this conversion leads to the accumulation of unfolded or misfolded protein and production of insoluble ?brs? The abnormalities in the gene level has been discusses in this study

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