A Study on Utility of Serum Prostate Specific Antigen Level and USG of Prostate to Differentiate Most Common Benign Diseases and Carcinoma of Prostate Gland
Author(s): Shree Kumar Chinmayananda Mishra, Binod Kumar Sahu, Debasis Debadatta Behera, Somanath Sethi* and Sanjukta Dixit
Abstract
Various studies have been conducted in the world to find out the correlation between the histopathology with the serum PSA level of different prostatic diseases. The serum PSA level is raised above 10 mg/ml in carcinoma and between 0 to 4 ng/ml in the benign prostatic lesion. Our study was intended to find the correlation of histopathology of prostatic diseases with serum PSA levels and ultrasound findings. Clinical history, ultrasound findings and serum PSA levels were collected from the patient’s record and a histopathological study was done in 114 cases between January 2015 to January 2017. Out of 114 cases studied histopathological 14 cases were adenocarcinoma, 14 cases were prostatic intraepithelial neoplasia and rest were BHP with or without prostatitis. The mean serum PSA level (39.27ng/ml) in malignancy cases was statistically significantly higher than that (7.25ng/ml) of benign conditions. Only 6.98% of BPH were found below 4ng/ml serum level. Serum PSA level 4-10ng/ml was the ‘grey zone’, at this level around 85% of BPH and PIN cases were overlapped with 28% of carcinoma cases. Out of all ultrasound findings suggestive of carcinoma, only 57.1% of cases were confirmed to be carcinoma by histopathological study.