A Study Showing Association between Hscrp and S. Cholesterol Level in Overweight and Obese Patients in Tertiary Care Centre In Gujarat, India
Author(s): Varshit Hathi and Hiren Makwana
Obesity is rapidly growing health problem in both developed and developing countries. In adults, obesity is associated with hyperinsulinemia, insulin resistance, dyslipidemia, and vascular dysfunction. C - reactive protein (CRP), formerly considered solely as a biomarker for inflammation, is now viewed as a prominent partaker in endothelial dysfunction and atherosclerosis. The present study aims to establish correlation between elevated hscrp levels and elevated serum cholesterol levels in overweight and obese patients. The present study was undertaken at a tertiary care center in Gujarat, India for a period of 2 years. Inclusion criteria includes healthy males and females more than 18 years with body mass index ≥ 25kg/m2 whereas all the comorbidities like diabetes mellitus, hypertension, stroke, coronary artery disease is excluded. There was statistically significant positive correlation between elevated s. cholesterol level and HSCRP level (elevated s. cholesterol: normal s. cholesterol ratio of HSCRP is 2.96: 1.68, z value 5, p value < 0.0012). Data shows that there is more risk of future coronary events when there is combined elevation of s. cholesterol and HSCRP, but there may also be risk of future atherosclerosis and other coronary events when s. cholesterol is normal and HSCRP is elevated, as HSCRP is surrogate marker of inflammation and indirect predictive risk factor for atherosclerosis and other coronary events.