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Anti-Acute Myelogenous Leukaemia Effect of the Ethanolic Extract of the Indian Rose | Abstract

Journal of Research in Medical and Dental Science
eISSN No. 2347-2367 pISSN No. 2347-2545

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Anti-Acute Myelogenous Leukaemia Effect of the Ethanolic Extract of the Indian Rose

Author(s): Sanjeev Mittal*, Heenu Dhar, Jigar Haria, Durgesh Wadhwa, Sandeep Kumar

Abstract

Leukaemia has emerged as one of the most lethal of the cancers in the modern era. Out of all Leukaemia, Acute Myelogenous Leukaemia (AML) is the most notorious. The treatment regime being expensive & toxic has led to a world-wide hunt for alternate sources of anti-AML agents. In the various traditional systems of medicines, the Indian rose (Rosa indica) has been recorded as having various health ?e?e??ts? In this paper, the Ethanolic extract of Rose was investigated for its anti-AML activity. The investigators treated both the AML cell line, HL-60 & the Normal Human Embryonic Kidney cell lines (NHEK) with varying doses of the Rosa indica’s Ethanolic extract for 24 h. Based on the current observations, the Rosa indica’s Ethanolic extract induced growth inhibition having IC50 44.44 µg/ml. Moreover, the ethanolic extract showed negligible activity against normal cell lines. Based on these ???d???s? it can be safely assumed that the ethanolic fraction of the Indian Rose can be utilized as an anti-AML agent.

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