Anti-Cancer and Antimicrobial Activity of Novel Bacterium Brevibacterium Sp. from Saudi Arabia Peninsula
Author(s): Abdulwahab Ali Abuderman
Abstract
Widespread use of antibiotics is leading to wide spread of multi drug resistance posing a global burden to the health care sector. Species of Brevibactrium has been known having potential pharmaceutical importance mainly targeting cancer and other diseases. Pharma giants are now focusing on the terrestrial environment to isolate important medical compounds embedded in this natural ecosystem. Marine samples were collected from UQAIR region and tested for anti-cancer and microbial activity using standard protocols. The results shows that isolated stains have potential anti-cancer and antimicrobial activity and strains have been identified by 16s ribosomal DNA (rDNA) sequence. The antibacterial activity of ethyl acetate crude extracts at the concentration of 10 mg/well was assayed by agar well diffusion method against pathogens- Staphylococcus aureus (ATCC-29213) and E. coli (ATCC 25922). The results obtained from in vitro cytotoxicity study of MCF-7 (IC50-17.3), HeLa (IC50-26.2) and HCT-116 (IC50-29) have optimal anticancer activity comparing to standard. In conclusion, the bacteria isolated from sea water showing promising results and active bioactive compounds isolated from marine atmosphere may be used to explore the active molecules have the potency of anti-microbial and anticancer activity.
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