Antimicrobial Peptide Cathelicidin and Vitamin D Receptor Gene Polymorphism in Oral Health
Author(s): Nireeksha, Mithra NH, Suchetha KN
Background: Anti-microbial peptides and vitamin D levels in saliva, GCF plays an important role in oral health and its
maintenance. The peptide levels are regulated by the Vitamin D cathecidilin pathway and their association and influence on
oral health is of outmost importance. The aim of the present review article is to establish the aim is to establish a relationship
and possibly the role of Cathelicidins and Vitamin D receptor gene polymorphism in relation to oral health.
Methodology: The (PRISMA) Preferred Reporting Items for Systematic Review Ad Meta-Analysis were used for reporting
this systematic review. The study protocol has been approved by all co-authors .The study has been registered at the (NHR)
National Institute for Health Research under the Prospero ID: CRD42020200946.
Results: A total of 102 articles were retrieved through electronic database search .After evaluating the title, abstract and
full text of these articles only 7 were selected for the present systematic review. However 3 articles were excluded because
they were classified as high risk of bias according to PRISMA guidelines. Out of 7 studies selected,4 were classified as low risk
bias and 3 were classified as moderate risk bias.
Conclusion: The current evidence suggests anti-microbial peptide LL-37 and vitamin D receptor gene polymorphism plays
an important role in caries prevalence and periodontal health.
Highlight: Understanding the role of antimicrobial peptides in saliva helps in enhancing focus on the effect of these
components on oral health and its maintenance.