Clinical profile of severe Covid-19 patients with sepsis associated Multiorgan dysfunction syndrome
Author(s): Ankita Thakur, Sanket Bakshi, Sourya Acharya*, Samarth Shukla
Background: The uninhibited spread of a novel coronavirus termed as severe acute respiratory disease coronavirus 2 (SARS-CoV-2) by the International Committee on Taxonomy of Viruses (ICTV), has led to the emergence of the coronavirus disease 2019 pandemic worldwide, more popularly known as the COVID19 pandemic. There have been over 86 million global confirmed cases till date, and the disease is known to have a 2.2% case fatality rate, having claimed over 1.87 million lives. Initially having being regarded as a purely respiratory disease with symptoms of viral pneumonia such as fever, fatigue, dry cough, and lymphopenia, Covid19 is now also known to wreak havoc on organs such as the kidney, heart, liver and on organ systems such as the blood and the immune system and lead to development of sepsis induced multiorgan dysfunction syndrome. Many older patients with existing comorbidities such as cardiovascular disease, liver disease, kidney disease or malignant tumors, have been recorded to have a more severe infection and have reportedly been at a higher mortality risk. Hence there is a need to be more attentive of the potential multi-organ injuries and to determine the factors that contribute to their progression in order to prevent the worsening prognosis that has come to be associated with COVID-19. Objectives: To determine epidemiological profile of the patients with severe covid 19 infections associated with multi-organ dysfunction syndrome. To correlate clinical, biochemical and radiological profile of Covid patients with sepsis. To assess the outcome (Discharge, death and duration of ICU stay) in Covid 19 patients with sepsis. Methodology: The data would be collected from the medical profiles of the patients severely infected with Covid 19, being treated according to the guidelines issued by WHO. The group of cases progressing further to septicemia will be compared with the control group of the severe covid cases not landing into sepsis. The outcomes of the cases will then be analyzed based on the clinical parameters. The study will be conducted in the states of Maharashtra, Uttar Pradesh and Delhi as these are amongst the worst hit states in the second wave of Covid 19. Results: The study would play a key role in in assessing the epidemiological as well as the clinical parameters leading to the MODS in severe Covid 19 infections associated with sepsis Conclusion: The results concluded from this study could possibly put a curb on the worsening prognosis by identifying a particular set of factors beforehand.