Cognitive Dysfunction in Patients with Systemic Lupus Erythe | 89507

Journal of Research in Medical and Dental Science
eISSN No. 2347-2367 pISSN No. 2347-2545

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Cognitive Dysfunction in Patients with Systemic Lupus Erythematosus: A Case Control Study

Author(s): Muhammad Amjad Kalhoro*, Mehwish Abrar, Shahtaj Adil Shah, Safia Bano, Nisar Ahmed Khokhar and Mahesh Kumar


Aim: To explore the incidence of cognitive impairment in individual having Systemic Lupus Erythematosus. Study Design: Case control study. Place and duration: Bilawal Medical College Jamshoro Pakistan, from rom September 2019 to September 2020. Methodology: Total 31 female patients with neuropsychiatric Systemic Lupus Erythematosus (nSLE) and thirty-one cognitively healthy women with Systemic Lupus Erythematosus (Control group) participated in the study. The researchers employed single-photon emission computed tomography to obtain information on sociodemographic, clinical, neuropsychological, & SLE-related markers. Results: When it came to cognitive complaints, 22.6 percent of those with nSLE reported them, compared to 6.5 percent in the control group (p=0.147); the frequency of cognitive dysfunction was 32.3 percent in those with nSLE, compared to 6.5 percent in the control group (p=0.01). Overall, the nSLE group seemed to be impaired in all cognitive domains at the same level, and there were correlations between cognitive dysfunction and less skilled occupation (r=0.41; p=0.02). Conclusion: In nSLE, cognitive impairment is rather common, and it seems to have a detrimental impact on social functioning. A number of interconnected elements (such as SLE-related factors, drugs, and psychosocial factors) seem to have a role in cognitive impairment and cognitive complaints in nSLE patients.

Share this article