Comparative Evaluation of Diclofenac and Ketorolac Transdermal Patch for Pain Management Post Periodontal Surgical Procedure-A Clinical Trial
Author(s): Gaurav N Ketkar and Sankari Malaiappan*
Abstract
Background: Transdermal delivery offers several benefits over oral delivery, including smooth, continuous drug delivery, increased bioavailability, and reduced drug-drug interactions. Patches can be easily applied by the caregiver, and they provide a visual cue that the medication has been administered. Aim: To evaluate analgesic efficacy of the ketorolac vs. diclofenac dermal patch post periodontal surgical procedures. Material and methods: Sample size (30) was calculated using G-power with the power set at 95%. All included individuals were randomly divided into 2 study groups. Group1 received diclofenac and group 2 received a ketorolac transdermal patch. The patch was applied immediately after the periodontal flap surgery. Number of rescue medicine and VAS scores for all the individuals was recorded at 3 hours and 6 hours post operatively. Results: Diclofenac transdermal patch was found to me more effective in pain relief than that of the ketorolac patch. Number of rescue medicines consumed by the individuals in the ketorolac patch was significantly higher than that of the diclofenac group. No sex predilection was seen in any of the results. Conclusion: Diclofenac transdermal patch proved to be much better for pain management post periodontal surgical therapy.