Comparison of Efficacy of Trypsin, Chymotrypsin and Bromelain with Dexamethasone and Serratiopeptidase in Postoperative Sequelae in Mandibular Third Molar Surgery-A Randomised Controlled Trial
Aim: The aim of the study was assessing the efficacy of trypsin+chymotrypsin + bromelain with dexamethasone+serratiopeptidase tablets in postoperative wound healing in surgical removal of mandibular third molars impaction. Materials and Methods: A prospective randomized study conducted with 40 patients that required removal of mesio angularly impacted mandibular third molar. The systematic statistical analysis was performed after the data collection was done. Patients were categorized into two groups (Group 1: dexamethasone+serratiopeptidase , Group 2 : trypsin+chymotrypsin + bromelain ) in a crossover manner .Subjective and objective observations recorded that include age, gender, and pain score using visual analog scale . Each patient was evaluated using a visual analogue scale.trypsin+chymotrypsin + bromelain Results: Pain intensity at the postoperative 1st, 3rd, 5th, 7th day postoperative was less in dexamethasone+serratiopeptidase group than trypsin+chymotrypsin+bromelain group and there was significant difference seen statistically (p<0.001).Swelling and Trismus were not statistically significant, however there were significant reduction in Swelling and Trismus on 3rd day. Conclusion: No statistically significant difference was noted between two groups with respect to pain and swelling, however in case of trismus there was a statistically significant difference between the two groups. Clinically patients on dexamethasone had better relief with regards to pain, trismus and swelling when compared to the trypsin group. Use of Dexamethasone postoperatively following surgical removal of mandibular third molar provided better relief with regards to the above parameters.