Correlation serum level of 25(OH)D and bone density in type 2 diabetes mellitus patients
Author(s): Muhammad Reagan, Surya Darma, Alwi Shahab, Radiyati Umi Partan and Hermansyah
Abstract
Bone density has positive relationship with levels of vitamin D, that reduce the risk of fracture. Some studies shows that vitamin D deficiency is not only related to skletal disease, but also to non-skletal disease such as T2DM. Vitamin D plays an important role in the regulation of blood glucose through the effect of pancreatic beta cell secretion and insulin sensitivity. To investigate correlation between serum level of 25(OH)D and bone density in type 2 diabetes mellitus patients. Observational study with cross sectional design at Internal Medicine Polyclinic Dr. Mohammad Hoesin Palembang Hospital from November 2014 to April 2015, and the result analyzed with statistical correlation. The subjects were taken by consecutive sampling in patients with T2DM who met inclusion criteria. Of 380 people who sought medication, 42 subjects met the inclusion criteria. There were 22 patients with low bone density (19 osteopenia and 3 osteoporosis), and 20 patients with normal bone density. Mean serum level of 25(OH)D in group with normal BMD of lumbar and femur was 19.48±6.75ng/ml, and in group with osteopenia and osteoporosis was 21.54±6.14ng/ml and 17.17±5.66ng/ml respectively. There was no significant correlation of 25(OH)D serum level with lumbar and femur bone density (p<0.05). There is no correlation between levels of 25(OH)D serum and bone density in T2DM patients at Internal Medicine Polyclinic of Mohammad Hoesin Hospital.
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