Diurnal Variation of Uric Acid and its Correlation with Certain Hormones: A Physiological Review
Previous studies showed a diurnal rhythm of uric acid. The mean serum uric acid value between 0800-0900 hours was higher than that observed between 1700-1800 hours. Oxidative stress is traditionally characterized as by imbalance among oxidant and antioxidant factors, occurs commonly in Mets. Antioxidant’s system including enzymes like superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and non-enzymatic substrates like ferritin, transferrin, and uric acid controls oxidative stress. Uric acid is an inactive metabolic result of purine catabolism, has been as of late implicated in various long term illness states, including arterial blood pressure, metabolic condition, diabetes, non-alcoholic fatty liver disorders, and chronic renal disorders. Raised uric acid may end up being one of the more significant remediable problematic factors for metabolic and cardiovascular disorders. A negative correlation is found between the levels of endogenous melatonin and UA. A positive correlation is found between the levels of cortisol and UA. Mets are characterized by hyperactivity of the HPA axis, which leads to “functional hypercortisolism.”. Uric acid level is linearly correlated with FT3 and FT4, but not with TSH. In conclusion, catabolic hormones have positive correlation with serum uric acid while hormones which decrease basal metabolism have negative correlation with serum uric acid levels.