Effect of Some Nutritional Supplement on the Cerebellum against Cyclophosphamide Toxicity
Author(s): Ali Hassan A Ali*, Shaban Ragab Ibrahim, Abdulrahman M Alkassar Alanazi, Hamad Mesfer H Alatif, Abdulrahman M Almalki, Bandar Suliman S Alsultan, Bakheet Mulfi S Alrashdi, Yousef K Alhuzaimi
The cerebellum is the largest part of the hindbrain. As an important part of nervous system, it can be affected by oxidative stress. Dietary supplements had been proved that they have antioxidants properties that may protect our bodies against the effects of free radicals. One of these supplements is Aphanizomenon flos-aquae (AFA) that has health-improving effects especially on the nervous system. Cyclophosphamide (CP) is a widely used medication in chemotherapy and can cause oxidative stress. This study was conducted to investigate the role of AFA in preventing cyclophosphamide-induced adverse effects on the cerebellum of treated rats with CP. It is an experimental study carried out in the period from January 2021 to August 2021. It was carried out on 36 rats with body weights of 270-300 g. The animals were divided into three groups. The first is control group, the second one is CP treated group, received one dose of CP at 100 mg/kg-1 BW), and last one is CP+AFA group, received orally extract of AFA after CP injection. The structures of the cerebellum were compared in the different groups histologically. Examined sections showed significant cellular injury in the second group in comparison to the control groups. The third group showed marked improvement in the changes that occurred compared to the second group. These results provide evidence that AFA has a protective effect as they reduced the cellular injuries in the cerebellum induced by cyclophosphamide.