Effect of tranexamic acid on postpartum vaginal hemorrhage in Sharieti Hospital of Bandar Abbas in 2014- 2015
Author(s): Azin Alavi, Farzaneh Atiqpour, Shahram Zare, Zinat Nasiri
Abstract
As a midwifery emergency, post-partum hemorrhage (PPH) might occur once a vaginal delivery or C-section is done. The prevalence of the hemorrhage has been estimated to range between 1 and 5 percent of deliveries. The present clinical trial was conducted as a randomized and controlled double-blind study in 2014-15 on 240 pregnant visitors of the natural delivery ward of Shariati university hospital in Bandar Abbas. The intervention group received 1 gram of venal tranexamic acid in 200 ml of normal saline while the control group received a placebo (distilled water) in 200 ml of normal saline injected within the second phase of the childbirth in 10 minutes. Patients’ information was recorded including the severity of hemorrhage, pre- and post-partum hemoglobin level as well as the clinical symptoms. The data were later analyzed via SPSS. The severity of hemorrhage was 313.9±46.8 in the intervention group and 729.3±199.6 in the control group which showed to be statistically significant (p˂.001). Moreover, hemoglobin showed to be reduced in the intervention group for .1±.16 and 1.72±.11 in the control group which was statistically significant (p˂.001). The present 9indings revealed that prescribed tranexamic acid can significantly cut down on blood loss and reduced hemoglobin in pregnant women.
<