Efficacy of Locally Applied K-Carrageenan on the Healing of Thermal Burn in Rat-Experimental Model: Histological Study
Author(s): Ammar Abood Kanber* and Enas Fadhil Kadhim
Abstract
Wound is damage or disruption to the normal anatomical structure and function. Carrageenan is sulphated polysaccharide found in Gigartina, Chondrus and Eucheuma species in the red algal family. Having anticancer, ƒnt‹?‹n?lƒmmƒtor› and renewal of tissues. Our study aimed to detect the role of kappa carrageenan in the burned skin wound repair. Skin burn were performed in the right and left cheek of 20 male rats (aged 7-8 weeks weighing 300-350 g). Burned skin rats were categorized into two equal groups. Burned areas of right side were treated with a local application of 1 ml of kappa carrageenan solution once daily (treatment group) and the left side receive no treatment (control group). After 5, and 10 days, 5 rats from each group were sƒcr‹?‹ced and tissue specimens from the wounded burn areas were obtained for histopathological inspection. Histopathological examination showed acceleration of wound healing in the kappa carrageenan treated rats as compared with control group during the experimental period. Progressions of wound healing were noticed with regard to re-epithelialization, wound closure and ‹n?‹ltrƒt‹on of ‹n?lƒmmƒtor› cells. In conclusion, local usage of Kappa Carrageenan has curative ef?‹c‹enc› to hasten wound healing.