Evaluating the Serum Homocysteine Level in the Patients with Chronic Obstructive Pulmonary Disease and its Correlation with Severity of the Disease
Author(s): Alireza Moayyedkazemi, Mohammad Hossein Rahimirad
Background: The patients with chronic obstructive pulmonary disease (COPD) are exposed to increased atherothrombotic events. The recent studies have shown that serum homocysteine (tHcy) and COPD are both risk factors for heart disease, and few studies have been conducted on serum tHcy level in COPD patients. This study aims to measure the serum tHcy level in the COPD patients and compare them with control group.
Method: A case control study has been performed on 40 COPD patients and 51 controls. The tHcy, blood gases, and spirometry were evaluated in COPD patients, and tHcy were investigated in the healthy adults (control group).
Results: The COPD patients had a higher serum tHcy level than the control group (19.51 mmol/L compared to 18.21 mmol/L), but the difference is not significant (p=0.5).
Conclusion: Although there was no significant correlation between tHcy and COPD; however further and larger studies are required for evaluating hyperhomocysteinemia in COPD patients.