Evaluation of Anti-inflammatory Effect of Cinnamaldehyde Mouthwash in Comparison with Chlorhexidine in Patients with Gingivitis
Author(s): Molania T, Saeedi M, Ehsani H,Azizi M, Moosazadeh M, Rostamkalaei S, Babaei Hatkehlouei M, Salehi M
Gingivitis literally means gingival inflammation which is the most common gum disease. Dental plaque is the main cause of gingivitis. Plaque control by dental brush and dental floss is not sufficiently effective. Therefore, the lateral use of chemical plaque control materials is recommended. Chlorhexidine mouthwash is known as the standard of periodontal treatment. But the side effects of chlorhexidine, such as color changes in the teeth and changes in the sense of taste and mucosal burning, led to an increase in efforts to find newer chemicals and herbs as alternatives. The aim of this study was to compare the effect of cinnamaldehyde and chlorhexidine mouthwash on gingival inflammation. 105 participants of both sexes (55 females and 50 males) with age range of: 20 to 45 years old with plaque-dependent chronic gingivitis were randomly divided into three groups (each group was 35): Group 1 (cinnamaldehyde 0.1%), group 2 (chlorhexidine 0.2%), group 3 (placebo). Dental plaque and gingivitis indices were measured at day one, one week later and then on day 21 after oral intake. Scores of periodontal variables were analyzed by SPSS 22 software, Kruskal-Wallis statistical tests, repeated variance analysis, Friedman test and post hoc test. Intra-group comparisons showed a significant difference between the plaque and gingival index in all groups (P <0/001). There was a significant difference between placebo and chlorhexidine groups in both PI and GI indexes. However, there was no significant difference between groups in plaque index and gingival index between cinnamaldehyde group and chlorhexidine mouthwash (P <0/001). Cinnamaldehyde mouthwash was helpful in improving gingival status and its effects were comparable to that of chlorhexidine without its significant side effects.