Evaluation the Effects of Dentifrice Containing Propolis Extract in the Control of Plaque and Gingivitis with Measuring il-1? and il-6 Salivary Cytokines levels, (clinical and immunological trial)
Background: Plants such as Propolis is a resinous substance obtained from the beehives that has antioxidant, anti-bacterial, anti-virus, antifungal, antitumor and anti-inflammatory activities. Gingivitis and periodontitis are diseases that involve the role of both the bacteria and the host immune response. Tooth brushing is effective in reducing levels of dental plaque. The aim of this study was to evaluate the effects of the toothpaste containing Propolis on control of plaque and gingivitis clinically and immunologically. Twenty patients diagnosed with generalized dental biofilm induced gingivitis were selected randomly to use propolis containing toothpaste (Ecodenta) and Colgate total toothpaste, for 7days for each type, and wash out period 7 days between them. Clinical periodontal evaluation is undertaken and saliva sample collection at baseline visit and after 7 days’ tooth paste usage to estimate interleukin-1β and interleukin-6 levels. The study detected significant reduction in clinical periodontal parameters modified sulcus bleeding index and modified Quigley Hein index also in the levels of interleukins in group Ecodenta after 7days in comparison to the Colgate toothpaste. The interleukins-1β and 6 could be used as inflammatory biomarkers in patients with gingivitis. The propolis addition to the toothpaste leads to a more decrease in plaque accumulation and inflammatory response in patients with dental biofilm induced gingivitis and greater gingival health improvement than the sole use of a toothpaste.