Formulation and Assessment of Allicin Based Medicated Chewing Gum
Author(s): Krishan Raj Singh*, Mohd Vaseem, Jasdeep Kaur, Nutan Sharma
Abstract
Oral medication delivery is the most recommended administration method due to its high patient compliance, easy to handle, painless treatment and does not require any special sterile setting. However, several medications taken orally meet physical, biological, and physiological barriers that reduce the therapeutic ef?‹c‹enc› of the medications before they reach the systemic circulation. Many researches have been conducted on uncovering alternative methods for oral drug delivery. Medicated chewing gums are an oral drug delivery system where drugs are embodied into the body via chewing gum. They have bene?‹ts of easy administration, increased bioavailability and long shelf life. In the present paper an attempt is made to fabricate a medicated chewing gum for treating ‹n?lammat‹on and masking taste of garlic. Medicated chewing gum comprises allicin, natural gum base, sugaring agent, ?‹llers? and plasticizers. The obtained medicated gum containing allicin was evaluated for appearance, taste, texture, consistency, elasticity and in vitro drug release activity.