GET THE APP

Genetic susceptibility to breast cancer in East Azerbaijan, Iran | Abstract

Journal of Research in Medical and Dental Science
eISSN No. 2347-2367 pISSN No. 2347-2545

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Genetic susceptibility to breast cancer in East Azerbaijan, Iran

Author(s): Mahdiyeh Pashaei, Jamal Eivazi Ziaei, Alireza Nikanfar, Babak Emamalizadeh, Seyyed Mojtaba Mohaddes Ardebili

Abstract

Background: Breast cancer is the most common cause of death among women in the world and in Iran. A number of risk factors for breast cancer development have been identified, among which the most important is positive family history. Alterations in different genes, including BRCA1, BRCA2, p53, CHEK2, PTEN, and ATM, also induce a predisposition for breast cancer. Among these changes, BRCA1 and BRCA2 alterations are the strongest drivers of breast cancer predisposition. Aim: This study was aimed at contributing to the development of appropriate methods for detecting genetic alterations, such as single or multiple exon deletions and amplifications, in the aforementioned genes. Materials and Methods: We used multiplex ligation-dependent probe amplification (MLPA) to determine genetic alterations in 150 female patients who hail from East Azerbaijan, Iran and suffer from familial breast cancer. Specifically, we investigated copy number changes in BRCA1, ATM, p53, CHEK2, and PTEN. Results: MLPA results showed no remarkable mutations in the study population. Conclusion: Size coverage is a critical factor for MLPA to accurately detect potential mutations in familial breast cancer susceptibility genes.

Share this article

cappadocia tours
cappadocia hotels
cappadocia hotel
cappadocia balloon
cappadocia balloon flights

paper.io

agar io

wormax io