Glioblastoma Multiforme with an Oligodendroglial Component: A Report of a Case with Review of Literature
Author(s): Mazaher Ramezani, Khashayar Rahmani, Masoud Sadeghi
Glioblastomas (GBMs) with an oligodendroglial component (GBMO) are mixed tumors composed of astrocytic and oligodendroglial cells. We report a 53-year-old man with a headache since last week after rising in blood pressure with urinary and fecal incontinence. The headache was persistent and mainly in frontal area and was present early in the morning with subsequent confusion. Computerized Tumor (CT) scanning showed a brain tumor, suspicious for GBM with med line shift. The patient was a candidate for emergency brain surgery and underwent surgery. Microscopically high-grade astrocytic tumor with the fibrillary background, foci of necrosis and focal oligodendroglial elements with clear cytoplasms and fried egg appearance was noted and pathologist reported “GBMO synonymous with grade IV oligoastrocytoma”. We emphasize that pathologists should be aware of this entity, thoroughly evaluate the specimen for oligodendroglial component and mention it in the report for prognostic and therapeutic significance.