Journal of Research in Medical and Dental Science
eISSN No. 2347-2367 pISSN No. 2347-2545

Histomorphometric and Histologic Evaluation of Nano-HA with and without PRGF in Bilateral Sinus Lift Augmentation: A Randomized Clinical Trial

Author(s): Mansour Meimandi, Anahita Ashouri Moghaddam, Gholam Ali Gholami, Fatemeh Mashadi Abbass and Mostafa Solati

Abstract

Background and Aim: Positive results were reported after application of plasma-rich in growth factors (PRGF) in sinus elevation augmentations. Furthermore, PRGF products are available in different formulations and using them along with different graft biomaterials possibly induces bone formation and remodeling. This study assessed the histologic and histomorphometric results of NanoBone® biomaterial with and without PRGF in bilateral sinus augmentations. Materials and Methods: In this randomized split-mouth clinical trial, 10 patients who needed sinus floor elevation were selected and activated liquid PRGF was obtained through centrifuge of their blood. The space between alveolar process and sinus floor were filled with NanoBone® + PRGF (test site) or NanoBone® alone (control site) post-surgery. After 6 months, the implants were inserted in the regions and bone specimens were obtained using trephine burs. The sections were prepared by the standard techniques and bone remodeling was examined in both groups. The data were subjected to paired t test. Results: In case sites, the mean new bone formation percentages were 30.29%±8.54 and 30.84% ±6.76 in control sites. The mean remnant particles were 26.16%±10.03 and 26.18%±10.09 in case and control sites respectively. No significant differences were noted between case and control sites regarding mean new bone formation and remnant particles. Chronic inflammation was noted in all specimens with dominant range of 10-30%. The giant cells were evident and all specimens showed bones of lamellar and woven types. Conclusion: Although no significant differences existed between the sites filling using NanoBone® with and without PRGF in bilateral sinus augmentations, the results are probably related to the lengthy time periods for specimen preparation and the type of bone materials used. Conclusion was that PRGF did not induce bone formation in the aforementioned period of time.

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