Histopathological Findings in Oral Lichen Planus: A Three-Year Report from Western Iran
Author(s): Hamid Reza Mozaffari, Seyedghasem Mirbahari, Masoud Sadeghi
Abstract
Oral lichen planus (OLP) is a chronic inflammatory disease with unknown etiology that is more prevalent in women. This study aimed to evaluate the prevalence of histopathological findings in OLP patients. During 2013 and 2015 in a retrospective study, one-hundred and three OLP patients were enrolled into the current study. The histopathological findings observed at the epithelial level and in the connective tissue were then analyzed and compared. We divided the patients into two age group (<50 years and ≥50 years). The mean age at diagnosis of the patients was 46.7 years that 41 patients (39.8%) were males. Out of 91 patients reported lesion sites, the most common site was right cheek (38.5%). The prevalence of reactive epithelial atypia (70.9%), epithelial hyperplasia (55.3%), focal parakeratosis (51.5%), neutrophils in the epithelium (50.5%), plasma cells in the connective tissue (40.8%), erosion fibrin deposit in the epithelium (18.4%), dysplasia (15.5%) and fibrous tissue hyperplasia (6.8%) were 70.9%, 55.3%, 51.5%, 50.5%, 40.8%, 18.4% and 15.5%, respectively. There was a significant difference between the incidence of erosion fibrin deposit in the epithelium and gender. Also, there was a significant difference between age groups with the incidence of dysplasia. In conclusion, the results showed that histopathological findings in OLP patients can effect on pathogenesis and progression of this disease and risk of malignancy in the patients. Therefore, it is better that the clinicians pay attention to these findings, especially dysplasia in future therapeutic strategies of the patients.631853
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