Immunohistochemical Expression of Integrin in OSCC in Relation to Tumor Grade
Author(s): Fatima Ghazi Al-Bayati* and Layla Sabri Yas
Abstract
Backgrounds: Squamous cell carcinoma (SCC) is identified as “a malignant epithelial neoplasm account 90% or more of oral lesion. Demonstrating squamous differentiation and have feature of keratin structure and intercellular bridges may be formed, so Integrin is a difficult of noncovalently complicated connected heterodimeric glycoproteins which is serve as adhesion particles of cell, co-operates with extracellular matrices (ECMs) like as laminin, fibronectin, vitronectin, and collagen, and have intercellular attachment function.
Objective: This study is aimed to demonstrate the intra cytoplasmic integrin expression in the tumor cell of (OSCC) in relation to different malignancy grade.
Materials and method: Seventeen case of formalin fixed -paraffin embedded (FFPE) tissue blocks that diagnosed as OSCC will be employed, all these cases were processed histologically and immunohistochemical to evaluate integrin expression.
Results: the positive expression of integrin increase from WDSCC to PDSCC, and statistically there is highly significant appear (P <0.01) in relation of Expression of integrin to grade.
Conclusion: Expression of integrin is increase with the histological grade of OSCC