Intrabony Defects Management Using Growth Factor Enhanced Matrix versus Platelet Rich Fibrin Utilizing Minimally Invasive Surgical Technique: A Randomized Control Study
The present study aimed to assess the regenerative effect of minimally invasive surgical technique (MIST) alone or combined with growth factor enhanced matrix (GEM 21S) versus platelet rich fibrin (PRF) in the treatment of intra-bony defects clinically and radiographically. Subject and Methods: 21 intra-bony defects in fifteen systemically healthy patients with moderate to severe chronic periodontitis were randomly classified into 3 groups, 7 sites each. Group ? treated by MIST alone, group ?? treated by MIST+ethylenediamine-tetraaceticacid (EDTA) + PRF and group III treated by MIST+EDTA+GEM 21S. The clinical parameters including probing pocket depth (PPD), clinical attachment level (CAL) and bleeding on probing (BOP), were recorded at baseline, 3, 6 and 9 months’ post-surgery. Cone beam computed tomography (CBCT) was performed at baseline and 9 months’ post-surgery to evaluate bone level and bone density. Results: Group II showed the marked improvements in clinical parameters followed by group III; while group I showed the least improvements. CBCT analysis showed statistically significant improvement in bone level, area of defect (AD) and bone density (BD) for the three studied groups at 9 months as compared to the mean baseline value with no significant differences between them at 9 months’ period. However, group III showed the best improvement followed by group II and group I. Conclusion: MIST with or without regenerative materials yielded improvement clinically and radiographically. The adjunctive use of PRF or GEM 21S provided superior benefits on the outcome of MIST for the treatment of intra-bony defects.