Investigate and Comparison of Serum Level Markers Lactate, hsCRP and CDT for Differentiating Bacterial Meningitis from Non-meningitis Patients with Similar Clinical Symptoms
Author(s): Samaneh Abyaz, Mohammad Taha Jalali, Alireza Ekrami, Gholamabbas Kaydani, Yousef Bashiri
Abstract
Meningitis, inflammation of the meninges membrane. Control of meningitis is one of the priorities of the World Health Organization, which based on the status of the disease in different countries, would be in need for different care systems. this study aimed to determine serum levels of biomarkers of hs-CRP, CDT and lactate in patients, and individuals with suspected meningitis and healthy subjects and to compare the value of these markers for differentiating patients with bacterial meningitis from patients with clinical symptoms similar to meningitis .In this fundamental- applied study, blood samples were collected from patients who had meningitis symptoms and referred to Razi medical educational center of Ahvaz. The amount of 5 CC of blood was taken from each patient. Then, in the standard laboratory terms the CDT, hs-CRP and lactate were measured by ELISA, Immunoturbidimetry, and colorimetric methods, respectively. Furthermore, the PCR molecular method was used for confirming the results. the serum levels of hs CRP, CDT and lactate in patients with bacterial meningitis did not show a significant relationship compared with a group of non-meningitis patients with similar clinical symptoms, whilst the rate of the serum levels of lactate and hs CRP in patients with bacterial meningitis compared with the control group without any clinical symptoms similar to meningitis has shown a significant increase .this study showed that the measurement of the serum levels of biochemical markers of lactate, CDT and hs-CRP cannot be useful tool to differentiate bacterial meningitis from non-meningitis patients group with similar clinical symptoms.
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