Journal of Research in Medical and Dental Science
eISSN No. 2347-2367 pISSN No. 2347-2545

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Investigating the Effects of Maternal Acrylamide Administration on Morphological Changes of Choroid Plexus and Lateral Ventricle in Rat Embryos

Author(s): Hengameh Dortaj*, Azam Hassanpour, Morteza Anvari, Maryam Yadegari

Abstract

Introduction: The potential toxicity of Acrylamide (ACR) in humans had become apparent with the detection of this substance in some processed foods. ACR due to the cooking method are increasingly used.

Aims: This study designed to investigate the effects of maternal ACR consumption on choroid plexus volume and capillaries and ventricular changes in rat embryonic.

Methods: Female pregnant Wistar rats were divided into two groups; an experimental and the control group (n=10). Animals in control group received drinking water while rats in experimental group were orally administered 10 mg/kg ACR solution. Pregnant rats were sacrificed on the 15th day of gestation. Their fetuses were taken out and after head fixation and tissue processing, serial sections were prepared and stained with haematoxylin-eosin (H & E). Choroid plexus and lateral ventricle volume and branches and length of the capillaries were measured and the results were analysed using SPSS version 21 and ANOVA statistical test.

Results: Results showed a significant reduction in Choroid plexus volume and capillaries length in experimental group compared to control group (p˂0.05), the branches of capillaries showed significant decrease (p˂0.001). Volume of lateral ventricle showed increase in experimental group compared to control group (p˂0.001).

Conclusion: Maternal ACR has toxic effect on the nervous system and induces structural changes in the development of choroid plexus and lateral ventricle.

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