Investigating the Effects of Rosa canina L. Fruit Extract in Animal Model of Alzheimer’s Disease
Author(s): Moein Salari, Taj Pari Kalantaripour, Khadijeh Esmaeilpour, Yaser Masoumi-Ardakani, Hakime Oloumi, Majid Asadi-Shekaari*
Abstract
This study was designed to evaluating the protective effects of RH extract (RHE) in a rat model of Alzheimer. Male rats were divided into three groups (n=8) including: Control (β-amyloid; 3 mμ ICV injection), RHE Vehicle (Normal saline) and RHE pre-treated groups (1350 mg/kg). Behavioural analysis Morris Water Maze (MWM) and histological study were done to reveal the protective potential of RHE in rats twelve days after Alzheimer induction. Enzyme-linked immunosorbent assay was used in the measurement of the Interleukine-6 (IL-6), Tumor necrosis factor (TNF-α), Malondialdehyde (MDA) and antioxidant enzymes. RHE markedly restored memory and learning impairments. RHE significantly decreased MDA, TNF-α and IL-6 levels in pre-treated group. In addition, RHE decreased the number of degenerated neurons in the hippocampal neurons of the RHE pre-treated rats. The results show that RHE has beneficial effects in a rat model of Alzheimer due to its anti-inflammatory and antioxidant properties.
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