Investigating the Relationship between Procalcitonin Serum Level and Response to Treatment in Urosepsis Patients
Author(s): Mohammad Shirvani, Seyed Zaker Saaidi Nejad, Navid Omidfar, Shahla Hosseini
Background and Aim: Urinary tract infection is a common and painful disease in humans. Rapid and timely diagnosis of sepsis and its differentiation from non-infectious causes that manifest with similar symptoms is very important because timely antibiotic treatment onset in patients with sepsis is very vital in reducing mortality and improving the final outcome of patients. This study was performed aiming to investigate the relationship between procalcitonin serum level changes and response to treatment in patients in 2016. Materials and Methods: In this study 15 women and 15 men of the patients over 18 years of age who were admitted to Yasouj Shahid Beheshti Hospital were selected. Then, urine culture and blood sample were taken simultaneously from the patients on day 5 and day 10 and two weeks after the start of treatment, and in case of negative urine culture in each one of the cultures, the procalcitonin serum level was measured. To analyze the data SPSS software was used. Findings: The mean and standard deviation of procalcitonin serum level before and after treatment were 8.88 ± 1.24 and 0.05 ± 0.01, respectively (p = 0.001). The mean and standard deviation of procalcitonin serum level before and after treatment in patients with complicated and uncomplicated urinary tract infection were 10.97 ± 1.46 and 0.54 ± 0.08, respectively (p = 0.001). Conclusion: Procalcitonin biomarker can be used in patients with urinary tract infection to evaluate the response to treatment and the duration of admission in the hospital and the duration of antibiotic therapy.