Modulated effect of Ammi majus L. on Psoriasis-Like Skin Inflammation Caused by Imiquimod in Vivo
Author(s): Ammar A Ramadhan* and Shihab H Mutlag
Abstract
Psoriasis is a chronic skin disease associated with an immune disorder, with clear manifestations and an easy clinical diagnosis. The purpose of this experiment is to evaluate the effect of Ammi majus on psoriasis- like inflammation induced by imiquimod in male mice. 40 mice used, divided into 5 groups (8 mice per group). All groups received imiquimod for psoriasis induction except for the first two groups, during all study days. The other third, fourth, and fifth groups were induced and treated once daily with wool fat, Ammi majus, clobetasol propionate, respectively, from the seventh day until the end of the experiment. The result showed that Ammi majus has anti-psoriasis effect by significantly lowering the PASI score, attenuating IMQ-induced cutaneous changes and significantly lowering the level of interleukins in the serum compared to the induced group. We concluded that the effect of Ammi majus against Imiquimod-induced psoriasis is probably through a mechanistic pathway that includes anti-inflammatory and anti-proliferative effects, and could be developed for therapeutic purposes in dermatology, especially psoriasis.