Novel cardiovascular risk factors in metabolic syndrome with and without coronary artery disease
Author(s): Bijoya Chatterjee, Tejas Shah, Ami Trivedi, Hardik Mahant, Vandana Katwa, Ketangiri Gosai
Background: India is home to one of the largest population of people with metabolic syndrome (MetS) which is a cardiovascular diseases (CVDs) risk factor. So there is a surging interest in identifying novel risk factors which could be helpful in preventing future morbidity and mortality and thereby reducing the burden of CVDs.
Aims: Aim of the current study was to determine the levels of novel risk factors namely hsCRP, ferritin, Lp (a) and uric acid (UA) in MetS subjects with and without coronary artery disease (CAD) and find out their association with components of MetS as well as other traditional risk factors.
Material & Methods: 150 subjects participated in the study. They were divided as Group I: fifty healthy controls, Group II: fifty MetS subjects without CAD and Group III: fifty MetS subjects with CAD. After clinical examination and anthropometric measurements, overnight fasting blood samples were collected for biochemical analysis.
Results: The novel CAD risk factors (hsCRP, ferritin Lp (a) and UA) were significantly higher in gr.III as compared to gr.II (p<0.05). The Pearson’s coefficient at 95 % confidence interval showed positive correlation of ferritin, hsCRP, Lp (a) and UA with other CVD risk factors. They negatively correlated with HDL-C.
Conclusions: This highlights a significant association of the novel cardiovascular risk factors notably ferritin, hsCRP, Lp (a) and UA in MetS subjects with CAD compared to traditional risk factors like TGs, WC and TC suggestive of their usefulness as markers.