Paracetamol: It?s Administration and Associated Effects | 93498

Journal of Research in Medical and Dental Science
eISSN No. 2347-2367 pISSN No. 2347-2545

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Paracetamol: It?s Administration and Associated Effects

Author(s): Singh VK*, Manu Modi, Manisha Rastogi, Ajay Bilandi, Nitin Kumar


Paracetamol also known as acetaminophen, it is the most widely used opioid in children for the relief of mild to severe pain. It is used as an analgesic as well as anti-pyretic. In this study, different formulations for administration, its mechanism of action, its pharmaco-kinetics and its long term effects like respiratory disease, gastrointestinal disease, cardiovascular disease, hepatotoxicity, asthma and so on, have been reviewed and analyzed based on the prior literature available, if the drug causes any effect on them or not. Since, mechanism of action of paracetamol is unclear, it is thought to include inhibition of cyclooxygenase 2 (COX2) and is available for over-the-counter preparation. Although the chronic effects are being observed but the occurrence of these adverse effects are quite uncommon. Future perspectives of this drug can be in the direction to further increase the ef?e of the drug and at the same time causing minimal long term effects

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