Periodontal Stem Cells for Bone Regeneration in Clinical Use: A Review of Literature
Author(s): Shireen Shidfar, Ahad Khoshzaban, Razieh Nejhadi, Zahra Zohri, Mohammad Taghi Baghani
Human periodontal stem cells were proved as a source of mesenchymal stem cells due to the presence of mesenchymal stem cell surface markers. This review of literature was aimed to assess clinical experiments, which have evaluated the efficacy of human periodontal stem cells for bone regeneration. The search strategy was based on the search strategy developed for MEDLINE (OVID) but revised appropriately for each database. We searched MEDLINE and EMBASE via OVID (1990 to October 2017) and no restrictions were placed on the language or date of publication when searching the electronic databases. Later all the references lists of the included studies would have been checked manually to identify any additional studies. None of the studies fulfilled our inclusion criteria and therefore no data analysis was conducted. There is little evidence relevant to this subject. There would appear to be a need for robust clinical trials to assess the efficacy of periodontal stem cells for regeneration.