Prognostic Values of Interleukin-6, C-Reactive Protein and Procalcitonin in COVID-19 Patients
Author(s): Karn Baranwal and Paramita Muntode*
Abstract
Coronavirus disease 2019 Or Covid 19 is an infection which is caused due to severe acute respiratory syndrome Coronavirus 2 is an ongoing pandemic in our world. A study was undertaken which revealed that pro calcitonin levels were elevated in patients who were suffering from moderate to severe coronavirus disease or acute respiratory distress due to the coronavirus. These levels decreased and gradually returned to normal with recovery as seen in discharged patients. But these levels rocketed in patients who had succumbed to this disease. Thus, we could predict that Procalcitonin levels could be used to grade the severity of COVID-19 pandemic. Hence this disease which was earlier thought to be a pure respiratory illness has been associated with multisystem organ dysfunction and heterogenous illness. Covid 19 affected patients can present with variable number of symptoms and can present with either and hyper inflammatory state or an endothelium dysfunction or maybe a thromboembolic phenomenon. C-Reactive protein and interleukin six also been elevated along with pro calcitonin levels in the hyperinflammatory stage of this disease. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first isolated in Wuhan from people with pneumonia who were indeed connected to the cases of acute respiratory illness. The disease began in Huanan seafood market in Wuhan and now it has been declared as a public health emergency worldwide. Till date, total of seven human infecting CoVs (HCoV) have been identified and they have been classified into two major groups namely, SARS-CoV, MERS-CoV, and SARS-CoV-2 which are considered to be highly pathogenic and another group consisting of HCoV 229E, NL63, OC43, and HKU1 which are considered to be low on their pathogenicity.