Relationship between Serum and Salivary Estimation of Glucose and TNF-? in Patients with Type-II Diabetes???A Correlative Study
Author(s): Vedavalli Subramanian, Muthukumar Santhanakrishnan*, Nizar Ahmed, M Ganesh, P Kennedy Kumar
Background: The relationship between diabetes mellitus and chronic periodontitis has gained immense significance amongst researchers worldwide. Diabetes mellitus and periodontitis has an established bidirectional relationship. Evidence suggest that in people with type II diabetes, periodontitis is associated with higher blood glucose levels and it worsens the complications of diabetes mellitus. Materials and Methods: This study was carried out in 18 subjects from the Outpatient Department of Periodontology, Sri Ramachandra Institute of Higher Education and Research, Chennai. Study was approved by the Institutional Ethical Committee. The selected subjects included Type 2 diabetes mellitus (T2DM) patients with chronic periodontitis (CP). They were provided non-surgical periodontal therapy (NSPT), scaling. Blood and saliva samples were collected from the subjects on the day of NSPT, baseline and after one month for estimation of glucose and TNF-α levels. Results: After NSPT, scaling there was a significant decrease in salivary and serum glucose levels (P<0.05) and an increase in the salivary and serum TNF alpha levels, though not statistically significant. Conclusion: This study proved saliva to be a useful indicator for glucose estimation. It also indicated that NSPT, scaling relieved the periodontal inflammatory status in T2DM patients with CP and were reflected by an improvement in the glycemic control as well. Nevertheless, there was no reduction in TNF – alpha levels following treatment.