Role of Adiponectin Level and Cystatin-C Level in Type II Diabetic Patients with Albuminurea
Author(s): Noor Thair Tahir*, Mithal R Alkubaisi, Raghd AY ALKhader, Abdilya R ALAbdaly and Luay Asaad Mahmood
Abstract
The aim of the present research was to study the role of adiponectin (ADPN) and Cystatin-C (Cys-C) levels in type 2 diabetes (T2D) patients with nephropathy complications, and their relation with the other clinical parameters. A total of 90 subjects that included 69 T2D nephropathy subjects, subdivided into three groups based on urinary albumin/creatinine ratio: group one=22 normo-albuminurea; group two=22 micro-albuminurea and group three=25 macro-albuminurea, compared with 21 healthy controls. Results showed statistically highly significant differences in the mean levels of ADPN and Cys-C on the overall ANOVA comparison of the studied groups (P<0.001). Also, the concentrations of ADPN and Cys-C were significantly increased in macro-albuminurea group compare to all 3 studied groups; micro-albuminurea (p<0.05), normo-albuminurea (p<0.01), and healthy controls (p<0.01) respectively. Moreover, the concentrations of ADPN and Cys-C were significantly increased in micro-albuminurea group compare to normo-albuminurea (p<0.05), (p<0.01) respectively, and healthy controls (p?0.01). Serum ADPN in normo-albuminurea showed highly significant positive correlation with HDL-Cho. Serum ADPN in micro-albuminurea were positively correlated with serum urea. ADPN levels in the macro-albuminurea group showed significant positive correlation with DBP. There was no statistically significant difference between sCys-C levels in normoalbuminuric patients and controls. There was no correlation found between ADPN and Cys-C. Conclusion: The findings of present study indicated that serum adiponectin could be utilized as a sensitive marker of early kidney disease in type 2 diabetes subjects whereas serum Cystatin–C might possibly have a prognostic value of early kidney disease in type 2 diabetes subjects.