Synthesis of Pharmaceutical Polyhydroquinolines Catalyzed by | 1789

Journal of Research in Medical and Dental Science
eISSN No. 2347-2367 pISSN No. 2347-2545

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Synthesis of Pharmaceutical Polyhydroquinolines Catalyzed by Cobalt (II) Complex as Reusable Catalyst

Author(s): Fahimeh Pakdaman, Sadegh Allameh, Mohammad Shaker


Polyhydroquinolines have been synthesized efficiently using a novel Co(II) complex based on5-nitro-N1-((pyridin- 2-yl)methylene)benzene-1,2-diamine(CoL2). This green catalyst has been utilized in a one-pot four-component Hantzsch condensation of dimedone, aldehydes, ethyl acetoacetate and ammonium acetate under solvent and free-solvent conditions. This method offers several advantages such as easy isolation of product, environmentally benign and excellent yields.


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