The Effect of Super Oxidized Water Mouthwash on the Level of IL 1? in Gingival Crevicular Fluid for Patients with Gingivitis Randomized Clinical Trial
Author(s): Ali Jawad M Ali, Saif S Saliem*
Background: One of the most predominant periodontal diseases is the plaque induced gingivitis. For the past 20 years, super-oxidized solutions have been shown to be powerful antimicrobials and disinfectants via oxidative damage. The taste is better than chlorhexidine and does not stain the teeth. Microsafe®, a recently presented super-oxidized solution for gingival care, offers a completely improved approach to treatment of gingivitis. Interleukin 1 beta is one from interleukins family and it is released by many cells such as macrophage to control immune response. Aim: The aim of the study is to determine the effect of super oxidized water mouthwash on the pro ??n??l??mm??tor?? cytokines (IL_1β) in the gingival crevicular ??lu??d compared to chlorhexidine in participants who continue to perform regular mechanical oral hygiene. Materials and methods: ort???????ve adult male patients with generalized gingivitis participated in the double blinded randomized controlled parallel study divided into three groups, two mouth rinses and distilled water( negative control) used during seven days periods as adjunctive to regular mechanical oral hygiene(brushing and ??loss??n????? one group received super oxidized water mouth rinses (Microsafe®) three times daily and the second group received Alcohol-free chlorhexidine 0.12% solution(kin gingival®) twice daily and the third group received distilled water (negative control). In the ????rst visit GCF collected from targeted sites (upper incisors, labial side) and then scaling and polishing were done. In the second the GCF was collected again from the same teeth. Results: The level of IL-1β showed a highly s????n??????c??nt differences in CHX group in the 2nd visit after treatment (46.062 versus 22.958 p=0.005) when compared to D.W and Microsafe® groups which also showed a s????n??????c??nt changes(65.517 versus 50.277 P=0.026, and 55.920 versus 46.351 p=0.010 respectively ). ????n??????c??ntl?? decreased between the study groups in level of IL_1β between the 1st visit and the 2nd visit (P=0.039) Conclusion: According to the results of our study, CHX was better than SOW and this was improving by immunological marker (IL-β). There was a positive reduction in the IL_ 1β after topical application of Microsafe® for one week but the duration of application must be continued more than 1 week to reach a good decrease of IL-1β in GCF which is a sign of less periodontal destruction.