The Effects of Cinnamomum verum on Intestinal GLUT5 Expression in Rat with High Fructose Corn Syrup Diet
Author(s): Maryam Sohrabi, Saadat Torabian
Introduction: High-fructose diet could lead to metabolic syndrome precede the type 2 diabetes. Metabolic syndrome is associated with insulin resistance and the cinnamon extract can regulated genes associated with insulin sensitivity. Little is known about the effects of cinnamon on the regulation of intestinal metabolically genes. This study investigates the effects of dietary cinnamon on intestinal glucose transporter-5 (GLUT5) in Wistar albino rats fed on commercial 15% High-fructose corn syrup.
Materials and Methods: Groups (A, B, C, D and E each: n=8) were feeding with standard diet in addition to a solution consisting of just water (A or Control), water plus high fructose corn syrup (B), water plus higher dose of cinnamon extract (C), water plus of mixed of fructose corn syrup+lower dose of cinnamon extract (D) mixed of fructose corn syrup+higher dose of cinnamon extract (E). The intestinal GLUT5 studied by immunohistochemical method.
Results: Mean positive GLUT5 cell number increased in the B and D groups compare to control (P<0.05). The average weight gain of in the B group increased compare to control (P<0.05). Hematoxylin-Eosin evaluation showed less histopathological changes in E group in comparison with the other groups. Intestinal morphology in D group was like that to control group.
Conclusion: GLUT5 expression in intestine respectively, increased and decreased by high-fructose syrup and cinnamon.