The Relationships Among Peripheral myelin protein 22, Ghrelin, Cholecystokinin level and Severity of Diabetic Gastroparesis
Author(s): Iryna Kostitska
Gastroparesis occurs in up to 30-50% of patients with chronic complications of diabetes and is associated with significant impairments in both quality of life and diabetic control. The ethical clearance of this study had been approved by bioethics unit of Ivano-Frankivsk National Medical University. The severity of diabetic gastroparesis (DG) was assessed by Gastroparesis Cardinal Symptom Index (GCSI) questionnaire and Gastric emptying rate (GER) with 13C-octanoic breath test (13C-OBT). Level of peripheral myelin protein 22 (PMP 22), ghrelin, cholecystokinin (CCK), were assayed by ELISA. The relationships was analysis by correlationspearman rho test, p<0,05. According to the questionnaire results, physical examination data as well as additional laboratory and instrumental investigations, mild DG was found in 16.7% patients with type 1 diabetes, moderate DG was observed in 15.5% patients and the signs of severe gastroparesis were present in 8.9% patients only. There was very strong correlation among PMP 22, ghrelin, CCK level and the severity gastroparesis in patients with type 1 diabetes.