The Role of Epithelial Mesenchymal Transition Process in Inflammatory Gingival Hyperplasia
Background: Gingival enlargement, the currently accepted terminology or an increase in the size of the gingiva. Local and systemic factors influence the gingival conditions of the patient. These factors result in a spectrum of diseases that can be developmental, reactive and inflammatory to neoplastic. Inflammatory gingival enlargement is the most common one; it is an inflammatory restraint to local irritant correlating with the gingiva.
Material and method: The study involved 15 tissue blocks of inflammatory gingival hyperplasia taken from the archives of oral pathology, laboratory of oral diagnosis department, collage of dentistry/university of Baghdad. Immunohistochemical expression of Vimentin, E-Chdaherin and α-SMA was assessed.
Results: Vimentin and E-Chadherin immunoreactivity of the connective tissue fibroblasts showed 100% positivity, while Alphasmooth muscle actin staining was mostly seen in the endothelial lined blood vessels with a few myofibroblast with in the connective tissue being stained positive. In this article we sought to investigate if the Epithelial mesenchymal transition theory participitated in the advancement of this benign lesion.