The Role of Polymorphism Gly972Arg IRS-1 Gene and C981T PTP-1B Gene on Insulin Resistance Young Adult Subjects with Low Birth Weight History
Author(s): Hikmat Permana, Sri Hartini KS Kariadi, Tri Hanggono Ahmad
Insulin resistance is including birth defects, insulin role in the fetus and Barker hypothesis, genotype thrifty, but all of these hypotheses suggest that low birth weight is places of exposure for a permanent metabolic abnormality. The Changes in the nature of IRS-1 causes insulin signal transduction disturbance, one of which is Gly972Arg gene polymorphism IRS-1 (Gly change Arg in codon 972). Transduction of insulin signaling of other pathways through a process of phosphorylation involving tyrosine phosphatase-1B protein (PTPN-1B / PTP-1B) . This study aims to study the role of polymorphism Gly972Arg gene IRS-1 and C981T PTP-1B gene on insulin resistance of young adult subjects with history of LBW. The research design was historical cohort study. Insulin resistance was measured according to the HOMA-IR formula. Gly972Arg gene polymorphism IRS-1 and C981T PTP1B gene analysis using the PCR-RLFP method using the enzyme smaI and EvaI. Polymorphism Gly972Arg gene IRS-1 was risk factor to develop insulin resistance. Low birth weight and polymorphism C981T gene PTP-1B were not risk factor to develop insulin resistance.