Research - (2021) Volume 9, Issue 7
Sleep Dose of Thiopentone Sodium Vs. Etomidate for Attenuation of Stress Response During Laryngoscopy
*Correspondence: Botta Bhagya Vardhan, Department of Anaesthesiology, Pain Medicine and Critical Care, Sree Balaji Medical College & Hospital Affiliated to Bharath Institute of Higher Education and Research, India, Email:
During the induction of anaesthesia there creates cardiovascular depression and causes stress which are mainly due to endotracheal intubation. These are the key elements that are to be considered especially for patients who are under cardiac risk. In this study group-E (Etomidate), anaesthesia was induced with Etomidate 0.3mg/kg and after 30 seconds Atracurium 0.5mg/kg was injected similarly group T patients were injected with thiopentone 3mg/kg and after 30 seconds Atracurium 0.5mg/kg was injected. From the results it was confirmed that etomidate is safer than thiopental in terms of providing haemodynamic stability to the patient during induction and post intubation.
Myocardial, Endotracheal, Ischemia, Etomidate
Stress response resulting from intubation, extubation and surgical stimulus can lead to some hemodynamic changes. Affects myocardial perfusion in a negative way by increasing myocardial oxygen consumption and cardiac workload, there by leading to ischaemia also increasing systemic arterial pressure and heart rate [1-2]. Some myocardial perfusion is created due to haemodynamic responses in a very negative way. Which can cause myocardial oxygen consumption to increase and elevating the cardiac workload eventually lading to ischemia.
This study aims to compare the haemodynamic effects of etomidate and thiopental by measuring cardiac output and arterial tension values at the stress response during laryngoscopy of patients undergoing elective surgery. Fallowing parameters are studied
• Heart rate.
• Systolic blood pressure.
• Diastolic blood pressure , saturation.
After institutional approval, this prospective study was conducted on 60 adult, ASA grade-I and 2 patients, aged between 18-60 years of either sex, undergoing elective surgeries m general surgery, orthopaedics, urology, and gynaecological surgeries. He patients were randomly assigned into two groups of 30 each.
• Group-E: Etomidate group.
• Group-T: Thiopentone group.
Patients were visited on the prev10us day of surgery, and the procedure was explained to them. All patients were given anxiolytic tablet diazepam 5-10 mg at bedtime on day before the surgery. A detailed medical history was taken, and systemic examination was carried out and relevant investigations were advised.
An informed written consent was taken from all patients and all patients kept fasting for 8 hours. Patients under following categories were excluded from the study.
• Patients below 18 years and above 60 years
• Morbidly obese patients
• Patients with history of drug allergy
• Patients with MPC class 3 & 4
• Patients with respiratory disease
• Patients with cardiovascular disease
• Patients with his tom of smoking, severe systemic disease, and neurological disease.
In group- E (Etomidate), anaesthesia was induced with Etomidate 0.3mg/kg and after 30 seconds Atracurium 0.5mg/kg was injected similarly group T patients were injected with thiopentone 3mg/kg and after 30 seconds Atracurium 0.5mg/kg was injected. The hemodynamic parameters namely pulse rate, systolic and diastolic blood pressure were recorded before induction, after induction, after intubation 1 min, 3 minutes and 5 minutes, Oxygen saturations were also recorded.
Both the groups I and II were statistically comparable about the mean heart rate up to induction period and it was statistically significant at post induction 1minute, 3 minutes and 5 minutes interval. Both the groups I and II were statistically comparable about the systolic blood pressure and it was statistically significant at post induction (P<0.05). Group E showed a stable systolic blood pressures when compared to Group T during induction & post intubation. About heart rates Group E showed a better stability when compared to Group T at these time frames. The oxygen saturation among the cases in both the groups were almost the same (Figure 1).
Figure 1: Oxygen saturation.
The mechanism of negative inotropic effects caused by intravenous anaesthetics is not exactly known, the use of etomidate, having less of a cardiac-depressive effect, is safer m cardiac patients, but the sympathoadrenal suppress1ve effects limit its usage it was found that the con tractility of the heart changed little, and heart rate, cardiac output and stroke volume remained stable in patients receiving etomidate. Grounds et al.  evaluated thiopental, etomidate and propofol in tracheal intubation by adding fentanyl, detected a significant decrease in SAP values in the group receiving only propofol, and there were significant increases in SAP values in the group receiving only thiopental and etomidate after intubation [3-10]. In this study, it proved that etomidate is safer than thiopental in terms of providing haemodynamic stability to the patient during induction and post intubation.
In both groups, during the study period, systolic blood pressure, diastolic blood pressure and heart rate with respect to time before induction were comparable. Following the administration of the induction dose Group T showed a significant decrease of systolic and diastolic blood pressure, increase in heart rate when compared to Group E.
No funding sources.
The study was approved by the Institutional Ethics Committee.
Conflict of Interest
The authors declare no conflict of interest.
The encouragement and support from Bharath Institute of Higher Education and Research, Chennai, is gratefully acknowledged. For provided the laboratory facilities to carry out the research work.
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Received: 14-Jul-2021 Accepted: 28-Jul-2021