A Comparative Study of Typhidot and Diazo Test in Early Detection and Diagnosis of Typhoid Fever in Children
The present study was to compare the sensitivity and specificity of Typhidot and Diazo test with blood culture as gold standard for diagnosis of Typhoid fever in children. This was a cross- sectional comparative study done on 100 children clinically suspected to have Typhoid fever at Sree Balaji Medical College and Hospital, Chennai. Blood sample was collected for Typhidot and blood culture and Urine sample was collected for Diazo test. The data collected was analysed using suitable statistical tests. It has been observed from the study that 26 children had positive blood culture. The sensitivity, specificity, positive predictive value and negative predictive value for Typhidot assay was 88.46%, 86.49%, 69.7% and 95.5% respectively. The sensitivity, specificity, positive predictive value and negative predictive value for Diazo test was 73.08%, 79.73%, 55.8% and 89.4% respectively .The present study includes Typhidot assay has higher sensitivity and specificity compared to Diazo test in diagnosis of Typhoid fever in children. Although Typhidot is superior to Diazo test, the present study shows a reasonable value of sensitivity and specificity for Diazo test. Hence it can be used in resource poor settings as it is economic and easy to perform.