Antibiotic Susceptibility of Klebsiella pneumoniae Isolated from Various Clinical Samples from a Tertiary Care, Chennai, India
Author(s): Kiran Madhusudhan and Bindu D*
Abstract
The genus Klebsiella of Enterobacteriaceae family is ubiquitous in nature. They cause many nosocomial and community acquired infections like pneumonia, urinary tract infections, wound infections, bacteremia and septicemia. Multidrug resistance is seen in Klebsiella which serves as the most common cause of increased morbidity and mortality. Klebsiella pneumoniae is major concern as drug resistance has evolved in them to last resort antibiotics. There are many mechanism that brings about the resistance are ESBL, Amp C beta lactamases and carbapenemases. This study aimed to know the prevalence and antibiotic susceptibility of various antibiotics to Klebsiella pneumoniae infections from various samples. This retrospective study was conducted in our tertiary care hospital during the period from January 2022 to May 2022. A total of 573 samples were tested during this period. The samples include blood, sputum, urine, and pus. Out of the 573 total samples tested,104 samples were identified as Klebsiella pneumoniae and the highest rate of isolation of Klebsiella pneumoniae was from wound sample (41.7 %) followed by urine (24.3 %) and also the same was reported high in surgical wards. The study showed male preponderance of Klebsiella pneumoniae when compared to females. The antibiotic sensitivity pattern was done by Kirby-Bauer's disc diffusion method and the sensitivity was noted to be higher to meropenem, imipenem and piperacillin-tazobactam. Thus, this study shows the prevalence rate of Klebsiella pneumoniae and sensitivity pattern of Klebsiella, which may help select appropriate antibiotics and prevent overuse and misuse of antibiotics.