Comparative Evaluation of the Anti-Inflammatory Potential of Three Different Anti Diabetic Natural Compounds (Piperine, Lupeol, Beta Sitosterol)
Author(s): Hooriyah, V Vishnu Priya*, J Selvaraj, Gayathri R and Kavitha S
Abstract
Background: Anti-inflammatory drugs interfere in the pathophysiological process of inflammation, to minimize tissue damage and provide greater comfort to the patient. The anti-inflammatory drugs in the market today cause a lot of side effects. Hence, it is important to develop new naturally occurring anti-inflammatory drugs. Aim: To evaluate and compare anti-inflammatory potential of Lupeol, Piperine and Beta Sitosterol. Materials and methods: Protein denaturation inhibition Assay was performed. All the information and reported studies concerning lupeol, piperine and beta sitosterol were summarized from library and digital databases (e.g. Google Scholar, Sci-finder, PubMed, Springer, Elsevier, MDPI, Web of Science, etc.). Statistical analysis was done using ONE-WAY-ANOVA and Duncan Multiple Range Tests. Data were analysed to check the statistical significance between the groups. Results: The results have shown that the protein denaturation inhibition of lupeol, piperine and beta sitosterol happened in a dose dependent manner with concentrations ranging from 100-500 µg/ml. It is also observed that beta sitosterol has the maximum anti-inflammatory potential followed by piperine and then lupeol. Conclusion: Hence lupeol, piperine and beta sitosterol have good anti-inflammatory potentials with beta sitosterol having the best anti-inflammatory potential in comparison to Lupeol and Piperine. After further in vivo studies and clinical trials, they can be recommended as potential anti-inflammatory drugs in the market.