Journal of Research in Medical and Dental Science
eISSN No. 2347-2367 pISSN No. 2347-2545

Emerging Role of the Neuronal Sweet Taste Receptor Heterodimer, T1R2+T1R3, in Cognitive Functioning

Author(s): Menizibeya O Welcome

Abstract

Diseases involving cognitive impairments present substantial burden to sufferers, families, caregivers and public health. Unfortunately, however, the mechanisms underlying cognitive disorders are yet to be fully unraveled. Taste receptors, initially discovered in the oral cavity, are now believed to be ubiquitously expressed in cells and tissues of the body, including central neurons. Recent investigations have shown that the sweet taste receptor heterodimer, T1R2+T1R3, plays a crucial role in cognitive functioning, suggesting that dysfunctions in sweet taste receptor signaling may underlie cognitive impairment in some brain pathologies. In this mini review, I integrate very recent data that suggest possible molecular mechanisms, linking neuronal sweet taste sensing to cognitive functioning. Future research directions and targeting of sweet taste receptor for potential treatment of brain diseases, involving sweet taste receptor dysfunctions are also discussed

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