Estimating the Levels of GlycA: A Novel Pro Inflammatory Biomarker in Periodontitis Subjects with and without Diabetes Mellitus
Author(s): Paladugu Devi Navya*, Kaarthikeyan G and Selvi Raj J
Abstract
Background: The NMR biomarker Glycoprotein acetylation [GlycA] is a novel glycoprotein acetylation biomarker. It's an NMR signal that comes from the glycan groups of some acute-phase glycoproteins [most notably -1-acid glycoprotein, haptoglobin, 1-antichymotrypsin, and transferrin]. GlycA has been examined extensively in the context of cardiovascular disease [CVD], where it was discovered to be highly linked to atherosclerosis and the risk of future CVD. Methods: The study enlisted the participation of 30 people. Based on gingival index, probing depth, and clinical attachment level, participants were separated into three groups: the healthy group (group 1; n=10), periodontitis without diabetes group (group 2; n=10), and periodontitis with diabetes mellitus group (group 3; n=10). Gingival crevicular fluid (GCF) samples collected from each subject were quantified for GlycA levels using an enzyme-linked immunosorbent assay. Results: The mean GlycA concentrations in GCF increased as the disease progressed from healthy to gingivitis to periodontitis. GlycA concentration was found to be highest in group 3 and lowest in group 1. GlycA levels also had a beneficial relationship with periodontal markers. Conclusions: In all groups, GCF GlycA concentrations were positively associated. Hence, GCF GlycA values were considered a marker of inflammatory activity in periodontal disease. However, GlycA deserves further consideration as a diagnostic target. To confirm positive associations, more large-scale investigations should be conducted.