Evaluation Pathogenesis Outcomes of Knee and Hip in Patients with Osteoarthritis Based on: Histopathological, Hematological, and Indicators of Inflammation
Introduction: Osteoarthritis (OA) is a biomechanical process in which the joints respond pathologically to mechanical stress, leading to articular cartilage damage and changes in other tissue. The present study focuses on some hematological and inflammatory indicators in both patients and control and histopathological change in the knee and hip of OA patients. Methods: Tissue samples were obtained from 50 OA patients (25 knee and 25 hip) during knee and hip replacement for histopathological study and 25 as control group for hematological and immune factors analysis. The tissue and blood samples were collected during the period October 2019 to April 2020. Results: the Histological study of knee and hip OA tissues (Femoral bone tissue and bone marrow tissue) expressed many histopathological changes such as fibrin deposition, congestion of blood vessels, and infiltration of inflammatory cells. There was no significant difference in concentration of Lymphocytes, Monocytes, and Neutrophils between control and tested groups as well there is no significant difference between tested groups in the patients group. Our results showed significant elevation in erythrocyte sedimentation rate (ESR) there was a significant difference in concentration of (ESR) between control and tested groups while there is no significant difference between tested groups in the patients group. While, there was a significant difference in concentration of C- reactive protein (CRP) between control and tested groups while there is no significant difference between tested groups in patients group. Conclusions: Histopathological, Hematological, and Immune factors are all associated with the progression of OA disease.